- Sears Roebuck & Co
- Second East Hills Apts
- Second Opinion Investment
- Second UP Church-Wilkinsburg
- Secure Communications Sltns
- Security Systems Of America
- Sembower-Mikesell Inc
- Sensus Technologies
- Service Master Co
- Sewing By Pat
- Shady Side Academy
- Shadyside Travel Agency Inc
- Shaffer Primary School
- Shalom Apostolic Church
- Shear Beauty Salon
- Shell
- Sherwin-Williams Paints
